Complete Reconstitution of a Highly-Reducing Iterative Polyketide Synthase

Highly-reducing iterative polyketide synthases are large multifunctional enzymes that make important metabolites in fungi, such as lovastatin, a cholesterol-lowering drug from Aspergillus terreus. We report efficient expression of LovB (the Lovastatin Nonaketide Synthase) from an engineered strain o...

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Autori principali: Ma, Suzanne M., Li, Jesse W.-H., Choi, Jin W., Zhou, Hui, Lee, K. K. Michael, Moorthie, Vijayalakshmi A., Xie, Xinkai, Kealey, James T., Da Silva, Nancy A., Vederas, John C., Tang, Yi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875069/
https://ncbi.nlm.nih.gov/pubmed/19900898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1175602
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