Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity

BACKGROUND AND PURPOSE: The discovery of the pharmacological functions of nitric oxide has led to the development of NO donor compounds as therapeutic agents. A new generation of ruthenium NO donors, cis-[Ru(NO)(bpy)(2)L]X(n), has been developed, and our aim was to show that these complexes are able...

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Detalles Bibliográficos
Autores principales: Silva, Jean Jerley Nogueira, Guedes, Paulo Marcos Matta, Zottis, Aderson, Balliano, Tatiane Luciano, Nascimento Silva, Francisco Ordelei, França Lopes, Luiz Gonzaga, Ellena, Javier, Oliva, Glaucius, Andricopulo, Adriano Defini, Franco, Douglas Wagner, Silva, João Santana
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2010
Materias:
Research Papers with Commentaries
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874849/
https://ncbi.nlm.nih.gov/pubmed/20105182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00524.x
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