Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity

BACKGROUND AND PURPOSE: The discovery of the pharmacological functions of nitric oxide has led to the development of NO donor compounds as therapeutic agents. A new generation of ruthenium NO donors, cis-[Ru(NO)(bpy)(2)L]X(n), has been developed, and our aim was to show that these complexes are able...

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Detalhes bibliográficos
Main Authors: Silva, Jean Jerley Nogueira, Guedes, Paulo Marcos Matta, Zottis, Aderson, Balliano, Tatiane Luciano, Nascimento Silva, Francisco Ordelei, França Lopes, Luiz Gonzaga, Ellena, Javier, Oliva, Glaucius, Andricopulo, Adriano Defini, Franco, Douglas Wagner, Silva, João Santana
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers with Commentaries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874849/
https://ncbi.nlm.nih.gov/pubmed/20105182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00524.x
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