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Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones
Mutations in myocilin cause an inherited form of open angle glaucoma, a prevalent neurodegenerative disorder associated with increased intraocular pressure. Myocilin forms part of the trabecular meshwork extracellular matrix presumed to regulate intraocular pressure. Missense mutations, clustered in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874607/ https://ncbi.nlm.nih.gov/pubmed/20334347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900282e |
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