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Profilin-1 over-expression upregulates PTEN and suppresses AKT activation in breast cancer cells
Profilin-1 (Pfn1), a ubiquitously expressed actin-binding protein, has been regarded as a tumor-suppressor molecule for breast cancer. Since AKT signaling impacts cell survival and proliferation, in this study we investigated whether AKT activation in breast cancer cells is sensitive to perturbation...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874249/ https://ncbi.nlm.nih.gov/pubmed/18937284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21618 |
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