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Loss of Profilin-1 Expression Enhances Breast Cancer Cell Motility by Ena/VASP Proteins

We previously showed that silencing profilin-1 (Pfn1) expression increases breast cancer cell motility, but the underlying mechanisms have not been explored. Herein, we demonstrate that loss of Pfn1 expression leads to slower but more stable lamellipodial protrusion thereby enhancing the net protrus...

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Autors principals: BAE, YONG HO, DING, ZHIJIE, ZOU, LI, WELLS, ALAN, GERTLER, FRANK, ROY, PARTHA
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990882/
https://ncbi.nlm.nih.gov/pubmed/19115233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21677
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