Profilin1 regulates PI(3,4)P(2) and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell migration through actin cytoskeletal regulation. Given the traditional view of profilin1 as a promigratory molecule, it is difficult to reconcile observations that profilin1 is down-regulated in various invasive...

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Detaylı Bibliyografya
Asıl Yazarlar: Bae, Yong Ho, Ding, Zhijie, Das, Tuhin, Wells, Alan, Gertler, Frank, Roy, Partha
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003040/
https://ncbi.nlm.nih.gov/pubmed/21115820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002309107
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