Accelerated leukemogenesis by truncated CBFβ-SMMHC defective in high-affinity binding with RUNX1

Dominant RUNX1 inhibition has been proposed as a common pathway for CBF-leukemia. CBFβ-SMMHC, a fusion protein in human acute myeloid leukemia (AML), dominantly inhibits RUNX1 largely through its RUNX1 high-affinity binding domain (HABD). However, the type I CBFβ-SMMHC fusion in AML patients lacks H...

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Autors principals: Kamikubo, Yasuhiko, Zhao, Ling, Wunderlich, Mark, Corpora, Takeshi, Hyde, R. Katherine, Paul, Thomas A., Kundu, Mondira, Garrett, Lisa, Compton, Sheila, Huang, Gang, Wolff, Linda, Ito, Yoshiaki, Bushweller, John, Mulloy, James C., Liu, P. Paul
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874204/
https://ncbi.nlm.nih.gov/pubmed/20478528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.03.022
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