Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.

Παρόμοια τεκμήρια

• The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
  ανά: Wek, S A, κ.ά.
  Έκδοση: (1995)
• Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.
  ανά: Ramirez, M, κ.ά.
  Έκδοση: (1992)
• The Translational Activator Gcn3 Functions Downstream from Gcn1 and Gcn2 in the Regulatory Pathway That Couples Gcn4 Expression to Amino Acid Availability in Saccharomyces Cerevisiae
  ανά: Hannig, E. M., κ.ά.
  Έκδοση: (1990)
• Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases.
  ανά: Raben, N, κ.ά.
  Έκδοση: (1992)
• Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.
  ανά: Vazquez de Aldana, C R, κ.ά.
  Έκδοση: (1994)