Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.

Míreanna Comhchosúla

• The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
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  Foilsithe: (1995)
• Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.
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  Foilsithe: (1992)
• The Translational Activator Gcn3 Functions Downstream from Gcn1 and Gcn2 in the Regulatory Pathway That Couples Gcn4 Expression to Amino Acid Availability in Saccharomyces Cerevisiae
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  Foilsithe: (1990)
• Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases.
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  Foilsithe: (1992)
• Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs
  le: Merritt, Ethan A, et al.
  Foilsithe: (2010)