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Different modes of TRAF3 ubiquitination selectively activate type I interferon and proinflammatory cytokine expression
Balanced production of type I interferons (IFN) and proinflammatory cytokines upon engagement of Toll-like receptors (TLRs), which signal via adaptors containing a Toll-IL-1-Receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor r...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2872790/ https://ncbi.nlm.nih.gov/pubmed/19898473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1819 |
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