Non-redundant and complementary functions of adaptor proteins TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

The adaptor and signaling proteins TRAF2, TRAF3 and cIAP1 and cIAP2 were suggested to inhibit alternative nuclear factor kappa B (NF-κB) signaling in resting cells by targeting NF-κB inducing kinase (NIK) to ubiquitin-dependent degradation, thus preventing processing of the NF-κB2 precursor protein...

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Main Authors: Vallabhapurapu, Sivakumar, Matsuzawa, Atsushi, Zhang, WeiZhou, Tseng, Ping-Hui, Keats, Jonathan J., Wang, Haopeng, Vignali, Dario A. A., Bergsagel, P. Leif, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671996/
https://ncbi.nlm.nih.gov/pubmed/18997792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1678
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