Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK

Recent studies suggest that nuclear factor κB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2. Here, we demonstrated that the degradation of NIK occurred upon assembly of a regulatory complex through TRAF3 recruitm...

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Detalhes bibliográficos
Main Authors: Zarnegar, Brian J., Wang, Yaya, Mahoney, Douglas J., Dempsey, Paul W., Cheung, Herman H., He, Jeannie, Shiba, Travis, Yang, Xiaolu, Yeh, Wen-chen, Mak, Tak W., Korneluk, Robert G., Cheng, Genhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676931/
https://ncbi.nlm.nih.gov/pubmed/18997794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1676
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