The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

TRPM2 is a calcium-permeable non-selective cation channel expressed in the plasma membrane and in lysosomes that is critically involved in aggravating reactive oxygen species (ROS)-induced inflammatory processes and has been implicated in cell death. TRPM2 is gated by ADP-ribose (ADPR) and modulated...

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Bibliographic Details
Main Authors: Starkus, John G, Fleig, Andrea, Penner, Reinhold
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
Subjects:
Molecular and Cellular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872729/
https://ncbi.nlm.nih.gov/pubmed/20194125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187476
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