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Inducible cutaneous inflammation reveals a pro-tumorigenic role for keratinocyte CXCR2 in skin carcinogenesis
Transgenic mice that overexpress PKCα in the epidermis (K5-PKCα mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong epidermal hyperplasia in response to application of 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We now show that hyperplasia is independent of inf...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2872171/ https://ncbi.nlm.nih.gov/pubmed/19118017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2490 |
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