MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis

MET is commonly expressed in many human squamous skin cancers (SCC) while Ras mutations are infrequent. The number of carcinogen induced mouse skin squamous tumors increases by 5 fold in transgenic mice where cutaneous MET is activated by overexpressing HGF (MT-HGF mice). Without carcinogen, squamou...

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Publicado no:Sci Signal
Main Authors: Cataisson, Christophe, Michalowski, Aleksandra M., Shibuya, Kelly, Ryscavage, Andrew, Klosterman, Mary, Wright, Lisa, Dubois, Wendy, Liu, Fan, Zhuang, Anne, Rodrigues, Kameron B., Hoover, Shelley, Dwyer, Jennifer, Simpson, Mark, Merlino, Glenn, Yuspa, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322206/
https://ncbi.nlm.nih.gov/pubmed/27330189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf5106
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