CXCR2 ligands and G-CSF mediate PKCα-induced intraepidermal inflammation

Transgenic mice overexpressing PKCα in the epidermis (K5-PKCα mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when PKCα is activated by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This inducible model of cutaneous inflammation was used to...

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Autori principali: Cataisson, Christophe, Pearson, Andrea J., Tsien, Margaret Z., Mascia, Francesca, Gao, Ji-Liang, Pastore, Saveria, Yuspa, Stuart H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560349/
https://ncbi.nlm.nih.gov/pubmed/16964312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27514
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