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What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?
We investigate several questions concerning the inference of the distribution of fitness effects (DFE) of new mutations from the distribution of nucleotide frequencies in a population sample. If a fixed sequencing effort is available, we find that the optimum strategy is to sequence a modest number...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Royal Society
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871813/ https://ncbi.nlm.nih.gov/pubmed/20308093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2009.0266 |
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