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Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies

The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of small populations. Properties of the DFE can be inferred by comparing the distributions of the frequencies...

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Main Authors: Keightley, Peter D., Eyre-Walker, Adam
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2219502/
https://ncbi.nlm.nih.gov/pubmed/18073430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.080663
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