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The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans
The distribution of fitness effects of new mutations is a fundamental parameter in genetics. Here we present a new method by which the distribution can be estimated. The method is fairly robust to changes in population size and admixture, and it can be corrected for any residual effects if a model o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Copyright © 2006 by the Genetics Society of America
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1526495/ https://ncbi.nlm.nih.gov/pubmed/16547091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057570 |
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