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The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans

The distribution of fitness effects of new mutations is a fundamental parameter in genetics. Here we present a new method by which the distribution can be estimated. The method is fairly robust to changes in population size and admixture, and it can be corrected for any residual effects if a model o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Eyre-Walker, Adam, Woolfit, Megan, Phelps, Ted
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Copyright © 2006 by the Genetics Society of America 2006
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526495/
https://ncbi.nlm.nih.gov/pubmed/16547091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.057570
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