Binding of PDZ-RhoGEF to ATP-binding Cassette Transporter A1 (ABCA1) Induces Cholesterol Efflux through RhoA Activation and Prevention of Transporter Degradation

ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux to apolipoprotein A1 (apoA-I) initiates the biogenesis of high density lipoprotein. Here we show that the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG bind to the C terminus of ABCA1 by a PDZ-PDZ interaction and prevent...

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Detalhes bibliográficos
Main Authors: Okuhira, Keiichiro, Fitzgerald, Michael L., Tamehiro, Norimasa, Ohoka, Nobumichi, Suzuki, Kazuhiro, Sawada, Jun-ichi, Naito, Mikihiko, Nishimaki-Mogami, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871504/
https://ncbi.nlm.nih.gov/pubmed/20348106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061424
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