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Transformation/Transcription Domain-Associated Protein (TRRAP)-Mediated Regulation of Wee1
The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry through the dual regulation of Wee1 and Cdc25 by the Chk1 effector kinase. Upregulation of Chk1 by mutation or overexpression bypasses the requirement for upstream regulators or DNA damage to promote a G2 cell cycle arrest. We screened in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Genetics Society of America
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2870978/ https://ncbi.nlm.nih.gov/pubmed/20194963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.114769 |
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