c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet.
Liver tumors arise in rats fed a choline-devoid diet without added carcinogens. We found amplification of the c-myc gene in 13/13 of these tumors. The amplification ranged from 2- to 70-fold and was accompanied by an increase in c-myc gene expression. Amplification of c-myc was larger in tumors of r...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1989
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2649891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2703 |
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