c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet.

Liver tumors arise in rats fed a choline-devoid diet without added carcinogens. We found amplification of the c-myc gene in 13/13 of these tumors. The amplification ranged from 2- to 70-fold and was accompanied by an increase in c-myc gene expression. Amplification of c-myc was larger in tumors of r...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Chandar, N, Lombardi, B, Locker, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2649891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2703
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