The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1

The transcription factor growth factor independence 1 (Gfi1) and the growth factor granulocyte colony-stimulating factor (G-CSF) are individually essential for neutrophil differentiation from myeloid progenitors. Here, we provide evidence that the functions of Gfi1 and G-CSF are linked in the regula...

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Detalles Bibliográficos
Autores principales: de la Luz Sierra, Maria, Sakakibara, Shuhei, Gasperini, Paola, Salvucci, Ombretta, Jiang, Kan, McCormick, Peter J., Segarra, Marta, Stone, Jim, Maric, Dragan, Zhu, Jinfang, Qian, Xiaolan, Lowy, Douglas R., Tosato, Giovanna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Phagocytes, Granulocytes, and Myelopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869559/
https://ncbi.nlm.nih.gov/pubmed/20203268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-246967
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