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Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.

The effects of intravenous administration of prostaglandins (PGs) were investigated in genetically narcoleptic Doberman pinschers. The treatment of narcoleptic dogs with PGE2 and PGE2 methyl ester, but not PGD2 and PGD2 methyl ester, induced a dose-dependent reduction of canine cataplexy, a dissocia...

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Detalles Bibliográficos
Main Authors: Nishino, S, Mignot, E, Fruhstorfer, B, Dement, W C, Hayaishi, O
Formato: Artigo
Idioma:Inglês
Publicado: 1989
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC286937/
https://ncbi.nlm.nih.gov/pubmed/2928344
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