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Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy.

The effects of intravenous administration of prostaglandins (PGs) were investigated in genetically narcoleptic Doberman pinschers. The treatment of narcoleptic dogs with PGE2 and PGE2 methyl ester, but not PGD2 and PGD2 methyl ester, induced a dose-dependent reduction of canine cataplexy, a dissocia...

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Détails bibliographiques
Auteurs principaux: Nishino, S, Mignot, E, Fruhstorfer, B, Dement, W C, Hayaishi, O
Format: Artigo
Langue:Inglês
Publié: 1989
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC286937/
https://ncbi.nlm.nih.gov/pubmed/2928344
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