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Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

The formation of single-stranded DNA (ssDNA) at double-strand break (DSB) ends is essential in repair by homologous recombination and is mediated by DNA helicases and nucleases. Here we estimated the length of ssDNA generated during DSB repair and analyzed the consequences of elimination of processi...

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מידע ביבליוגרפי
Main Authors: Chung, Woo-Hyun, Zhu, Zhu, Papusha, Alma, Malkova, Anna, Ira, Grzegorz
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869328/
https://ncbi.nlm.nih.gov/pubmed/20485519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000948
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