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Towards the assembly of heparin and heparan sulfate oligosaccharide libraries: efficient synthesis of uronic acid and disaccharide building blocks

The monosaccharide moieties found in heparin (HP) and heparan sulfate (HS), glucosamine and two kinds of uronic acids, glucuronic and iduronic acids, were efficiently synthesized by use of glucosamine hydrochloride and glucurono-6,3-lactone as starting compounds. In the synthesis of the disaccharide...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Saito, Akihiro, Wakao, Masahiro, Deguchi, Hiroshi, Mawatari, Aya, Sobel, Michael, Suda, Yasuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869207/
https://ncbi.nlm.nih.gov/pubmed/20473366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2010.03.077
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