Effect of G Protein–Coupled Receptor Kinase 1 (Grk1) Overexpression on Rod Photoreceptor Cell Viability

PURPOSE. Photoreceptor rhodopsin kinase (Rk, G protein–dependent receptor kinase 1 [Grk1]) phosphorylates light-activated opsins and channels them into an inactive complex with visual arrestins. Grk1 deficiency leads to human retinopathy and heightened susceptibility to light-induced photoreceptor c...

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Main Authors: Whitcomb, Tiffany, Sakurai, Keisuke, Brown, Bruce M., Young, Joyce E., Sheflin, Lowell, Dlugos, Cynthia, Craft, Cheryl M., Kefalov, Vladimir J., Khani, Shahrokh C.
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868427/
https://ncbi.nlm.nih.gov/pubmed/19834036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-4499
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