Replication independent DNA double-strand break retention may prevent genomic instability

BACKGROUND: Global hypomethylation and genomic instability are cardinal features of cancers. Recently, we established a method for the detection of DNA methylation levels at sites close to endogenous DNA double strand breaks (EDSBs), and found that those sites have a higher level of methylation than...

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Bibliographic Details
Main Authors: Kongruttanachok, Narisorn, Phuangphairoj, Chutipa, Thongnak, Araya, Ponyeam, Wanpen, Rattanatanyong, Prakasit, Pornthanakasem, Wichai, Mutirangura, Apiwat
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867818/
https://ncbi.nlm.nih.gov/pubmed/20356374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-70
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