Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been implicated, the molecular mechanism underlying this selectivity is unclear. In other cell types, the nucle...

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Detalhes bibliográficos
Main Authors: Wu, Raymond P., Hayashi, Tomoko, Cottam, Howard B., Jin, Guangyi, Yao, Shiyin, Wu, Christina C. N., Rosenbach, Michael D., Corr, Maripat, Schwab, Richard B., Carson, Dennis A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867719/
https://ncbi.nlm.nih.gov/pubmed/20368435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002890107
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