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Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy and contractile dysfunction. Recent work reveals that activation of the proteases calpain and caspase-3 is required for MV-induced diaphragmatic atrophy and contractile dysfunction. However, the mechanism(s)...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Whidden, Melissa A., Smuder, Ashley J., Wu, Min, Hudson, Matthew B., Nelson, W. Bradley, Powers, Scott K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867537/
https://ncbi.nlm.nih.gov/pubmed/20203072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00098.2010
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