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Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy and contractile dysfunction. Recent work reveals that activation of the proteases calpain and caspase-3 is required for MV-induced diaphragmatic atrophy and contractile dysfunction. However, the mechanism(s)...

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Autors principals: Whidden, Melissa A., Smuder, Ashley J., Wu, Min, Hudson, Matthew B., Nelson, W. Bradley, Powers, Scott K.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867537/
https://ncbi.nlm.nih.gov/pubmed/20203072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00098.2010
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