Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation

Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunction (VIDD). While the mechanisms responsible for VIDD are not fully understood, recent data reveal that prolonged MV activates autophagy in the diaphragm, which may occur as a result of increased cel...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Smuder, Ashley J., Sollanek, Kurt J., Nelson, W. Bradley, Min, Kisuk, Talbert, Erin E., Kavazis, Andreas N., Hudson, Matthew B., Sandri, Marco, Szeto, Hazel H., Powers, Scott K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767544/
https://ncbi.nlm.nih.gov/pubmed/29197632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.11.025
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