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Inhibition of FOXO-specific transcription prevents mechanical ventilation-induced diaphragm dysfunction

BACKGROUND: Mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, prolonged MV results in diaphragm weakness, which contributes to problems in weaning from the ventilator. Therefore, identifying the signaling pathways responsible for MV-induced diaphragm...

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Bibliografske podrobnosti
izdano v:Crit Care Med
Main Authors: Smuder, Ashley J., Sollanek, Kurt J., Min, Kisuk, Nelson, W. Bradley, Powers, Scott K.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400222/
https://ncbi.nlm.nih.gov/pubmed/25746508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000928
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