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Inhibition of FOXO-specific transcription prevents mechanical ventilation-induced diaphragm dysfunction

BACKGROUND: Mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, prolonged MV results in diaphragm weakness, which contributes to problems in weaning from the ventilator. Therefore, identifying the signaling pathways responsible for MV-induced diaphragm...

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Bibliographische Detailangaben
Veröffentlicht in:Crit Care Med
Hauptverfasser: Smuder, Ashley J., Sollanek, Kurt J., Min, Kisuk, Nelson, W. Bradley, Powers, Scott K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400222/
https://ncbi.nlm.nih.gov/pubmed/25746508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000000928
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