Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy and contractile dysfunction. Recent work reveals that activation of the proteases calpain and caspase-3 is required for MV-induced diaphragmatic atrophy and contractile dysfunction. However, the mechanism(s)...

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Main Authors: Whidden, Melissa A., Smuder, Ashley J., Wu, Min, Hudson, Matthew B., Nelson, W. Bradley, Powers, Scott K.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867537/
https://ncbi.nlm.nih.gov/pubmed/20203072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00098.2010
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