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Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm
Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy and contractile dysfunction. Recent work reveals that activation of the proteases calpain and caspase-3 is required for MV-induced diaphragmatic atrophy and contractile dysfunction. However, the mechanism(s)...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867537/ https://ncbi.nlm.nih.gov/pubmed/20203072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00098.2010 |
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