Knockout of Na(+)/Ca(2+) exchanger in smooth muscle attenuates vasoconstriction and L-type Ca(2+) channel current and lowers blood pressure

Mice with smooth muscle (SM)-specific knockout of Na(+)/Ca(2+) exchanger type-1 (NCX1(SM−/−)) and the NCX inhibitor, SEA0400, were used to study the physiological role of NCX1 in mouse mesenteric arteries. NCX1 protein expression was greatly reduced in arteries from NCX1(SM−/−) mice generated with C...

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Hauptverfasser: Zhang, Jin, Ren, Chongyu, Chen, Ling, Navedo, Manuel F., Antos, Laura K., Kinsey, Stephen P., Iwamoto, Takahiro, Philipson, Kenneth D., Kotlikoff, Michael I., Santana, Luis F., Wier, W. Gil, Matteson, Donald R., Blaustein, Mordecai P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867439/
https://ncbi.nlm.nih.gov/pubmed/20173044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00964.2009
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