Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair

To understand how multiprotein complexes assemble and function on chromatin, we combined quantitative analysis of the mammalian nucleotide excision DNA repair (NER) machinery in living cells with computational modeling. We found that individual NER components exchange within tens of seconds between...

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Bibliografiska uppgifter
Huvudupphovsmän: Luijsterburg, Martijn S., von Bornstaedt, Gesa, Gourdin, Audrey M., Politi, Antonio Z., Moné, Martijn J., Warmerdam, Daniël O., Goedhart, Joachim, Vermeulen, Wim, van Driel, Roel, Höfer, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2010
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Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867314/
https://ncbi.nlm.nih.gov/pubmed/20439997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909175
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