Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair

To understand how multiprotein complexes assemble and function on chromatin, we combined quantitative analysis of the mammalian nucleotide excision DNA repair (NER) machinery in living cells with computational modeling. We found that individual NER components exchange within tens of seconds between...

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Bibliografiske detaljer
Main Authors: Luijsterburg, Martijn S., von Bornstaedt, Gesa, Gourdin, Audrey M., Politi, Antonio Z., Moné, Martijn J., Warmerdam, Daniël O., Goedhart, Joachim, Vermeulen, Wim, van Driel, Roel, Höfer, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867314/
https://ncbi.nlm.nih.gov/pubmed/20439997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909175
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