Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair

To understand how multiprotein complexes assemble and function on chromatin, we combined quantitative analysis of the mammalian nucleotide excision DNA repair (NER) machinery in living cells with computational modeling. We found that individual NER components exchange within tens of seconds between...

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Hauptverfasser: Luijsterburg, Martijn S., von Bornstaedt, Gesa, Gourdin, Audrey M., Politi, Antonio Z., Moné, Martijn J., Warmerdam, Daniël O., Goedhart, Joachim, Vermeulen, Wim, van Driel, Roel, Höfer, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2010
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867314/
https://ncbi.nlm.nih.gov/pubmed/20439997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909175
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