A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant EGFR activity may cause cell transformation. Receptor-associated late transducer (RALT) is a feedback inhibitor of EGFR whose genetic ablation in the mouse causes phenotypes due to EGFR-driven excess cel...

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Autores principales: Frosi, Yuri, Anastasi, Sergio, Ballarò, Costanza, Varsano, Giulia, Castellani, Loriana, Maspero, Elena, Polo, Simona, Alemà, Stefano, Segatto, Oreste
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867293/
https://ncbi.nlm.nih.gov/pubmed/20421427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201002032
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