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A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant EGFR activity may cause cell transformation. Receptor-associated late transducer (RALT) is a feedback inhibitor of EGFR whose genetic ablation in the mouse causes phenotypes due to EGFR-driven excess cel...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Rockefeller University Press
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867293/ https://ncbi.nlm.nih.gov/pubmed/20421427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201002032 |
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