Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions

Currently the only therapy for botulinum neurotoxin A (BoNT/A) poisoning is antitoxin. Antidotes that are effective after BoNT/A has entered the motor nerve terminals would dramatically benefit BoNT/A therapy. Inhibition of proteolytic activity of BoNT/A light chain by metalloendoprotease inhibitors...

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Autori principali: Thyagarajan, Baskaran, Potian, Joseph G., Garcia, Carmen C., Hognason, Kormakur, Čapková, Kateřina, Moe, Scott T., Jacobson, Alan R., Janda, Kim D., McArdle, Joseph J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867082/
https://ncbi.nlm.nih.gov/pubmed/20211192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.02.014
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