Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms

PDZ domains most commonly bind the C-terminus of their protein targets. Typically the C-terminal four residues of the protein target are considered as the binding motif, particularly the C-terminal residue (P0) and third-last residue (P-2) that form the major contacts with the PDZ domain's “bin...

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Bibliographische Detailangaben
Hauptverfasser: Elkins, Jonathan M, Gileadi, Carina, Shrestha, Leela, Phillips, Claire, Wang, Jing, Muniz, João R C, Doyle, Declan A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867013/
https://ncbi.nlm.nih.gov/pubmed/20120020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.349
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