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Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms

PDZ domains most commonly bind the C-terminus of their protein targets. Typically the C-terminal four residues of the protein target are considered as the binding motif, particularly the C-terminal residue (P0) and third-last residue (P-2) that form the major contacts with the PDZ domain's “bin...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Elkins, Jonathan M, Gileadi, Carina, Shrestha, Leela, Phillips, Claire, Wang, Jing, Muniz, João R C, Doyle, Declan A
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley Subscription Services, Inc., A Wiley Company 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867013/
https://ncbi.nlm.nih.gov/pubmed/20120020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.349
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