DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer

PURPOSE: DNA methyltransferase-3B (DNMT3B) plays an important role in de novo CpG island methylation. Dnmt3b can induce colon tumor in mice with methylation in specific CpG islands. We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e.,...

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Библиографические подробности
Главные авторы: Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Baba, Yoshifumi, Kirkner, Gregory J., Chen, Li, Gokhale, Sumita, Hazra, Aditi, Spiegelman, Donna, Giovannucci, Edward L., Jaenisch, Rudolf, Fuchs, Charles S., Ogino, Shuji
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866637/
https://ncbi.nlm.nih.gov/pubmed/19470733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2383
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