JC Virus T-Antigen in Colorectal Cancer Is Associated with p53 Expression and Chromosomal Instability, Independent of CpG Island Methylator Phenotype

JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG island methylator phenotype (CIMP) has been suggested. However, no large-scale study has examined the rela...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Nosho, Katsuhiko, Shima, Kaori, Kure, Shoko, Irahara, Natsumi, Baba, Yoshifumi, Chen, Li, Kirkner, Gregory J, Fuchs, Charles S, Ogino, Shuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606122/
https://ncbi.nlm.nih.gov/pubmed/19107235
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge