JC Virus T-Antigen in Colorectal Cancer Is Associated with p53 Expression and Chromosomal Instability, Independent of CpG Island Methylator Phenotype

JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize β-catenin. A link between JCVT and CpG island methylator phenotype (CIMP) has been suggested. However, no large-scale study has examined the rela...

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Detalhes bibliográficos
Main Authors: Nosho, Katsuhiko, Shima, Kaori, Kure, Shoko, Irahara, Natsumi, Baba, Yoshifumi, Chen, Li, Kirkner, Gregory J, Fuchs, Charles S, Ogino, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606122/
https://ncbi.nlm.nih.gov/pubmed/19107235
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