DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer

PURPOSE: DNA methyltransferase-3B (DNMT3B) plays an important role in de novo CpG island methylation. Dnmt3b can induce colon tumor in mice with methylation in specific CpG islands. We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e.,...

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Detalhes bibliográficos
Main Authors: Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Kure, Shoko, Baba, Yoshifumi, Kirkner, Gregory J., Chen, Li, Gokhale, Sumita, Hazra, Aditi, Spiegelman, Donna, Giovannucci, Edward L., Jaenisch, Rudolf, Fuchs, Charles S., Ogino, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866637/
https://ncbi.nlm.nih.gov/pubmed/19470733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2383
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