Comprehensive Biostatistical Analysis of CpG Island Methylator Phenotype in Colorectal Cancer Using a Large Population-Based Sample

BACKGROUND: The CpG island methylator phenotype (CIMP) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent investigations have selected 5 promoters (CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1) as surrogate markers for CIMP-high. However, no...

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Autori principali: Nosho, Katsuhiko, Irahara, Natsumi, Shima, Kaori, Kure, Shoko, Kirkner, Gregory J., Schernhammer, Eva S., Hazra, Aditi, Hunter, David J., Quackenbush, John, Spiegelman, Donna, Giovannucci, Edward L., Fuchs, Charles S., Ogino, Shuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579485/
https://ncbi.nlm.nih.gov/pubmed/19002263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003698
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