Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Sestrins are conserved proteins that accumulate in cells exposed to stress and potentiate adenosine monophosphate-activated protein kinase (AMPK) and inhibit activation of target of rapamycin (TOR). We show that abundance of Drosophila Sestrin (dSesn) is increased upon chronic TOR activation through...

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Bibliografiske detaljer
Main Authors: Lee, Jun Hee, Budanov, Andrei V., Park, Eek Joong, Birse, Ryan, Kim, Teddy E., Perkins, Guy A., Ocorr, Karen, Ellisman, Mark H., Bodmer, Rolf, Bier, Ethan, Karin, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866632/
https://ncbi.nlm.nih.gov/pubmed/20203043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182228
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