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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
Sestrins are conserved proteins that accumulate in cells exposed to stress and potentiate adenosine monophosphate-activated protein kinase (AMPK) and inhibit activation of target of rapamycin (TOR). We show that abundance of Drosophila Sestrin (dSesn) is increased upon chronic TOR activation through...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866632/ https://ncbi.nlm.nih.gov/pubmed/20203043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182228 |
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